1609118-16-2

Upstream product

• 185384-36-5 N-(tert-butoxycarbonyl)-N-(prop-2-ynyl)aniline 
• 1018479-39-4 tert-butyl (E)-(4-hydroxybut-2-en-1-yl)(phenyl)carbamate 
• 77-78-1 dimethyl sulfate 
• 3422-01-3 tert-butyl phenylcarbamate 
• 22427-04-9 (E)-4-methoxybut-2-en-1-ol 
• 18857-03-9 4-methoxy-but-2-yn-1-ol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 22427-01-6 trans-1-Bromo-4-methoxy-2-butene 
• 62-53-3 aniline 

Downstream Products

• 1609118-11-7 (Z)-tert-butyl buta-1,3-dien-1-yl(phenyl)carbamate 
• 1609118-07-1 (E)-tert-butyl buta-1,3-dien-1-yl(phenyl)carbamate 

Relevant academic research and scientific papers

Copper-Catalyzed Regiospecific and 1,2-Regioselective Cyclopropanation of (1 Z)-1-Amino- and (1 Z)-1-Oxy-1,3-butadienyl Derivatives

The copper-catalyzed regiospecific and 1,2-regioselective cyclopropanation of (1Z)-1-amino- and (1Z)-1-oxy-1,3-butadienyl derivatives, which could be prepared by Z-stereoselective 1,4-elimination with α-aryl diazoesters was successfully demonstrated. This successful regiospecific protocol enabled the preparation of the corresponding 1-amino- and 1-oxy-2-vinylcyclopropane derivatives as almost single stereoisomers.

Stereoselective preparation of (1Z)- and (1E)-N-Boc-1-amino-1,3-dienes by stereospecific base-promoted 1,4-elimination

The base-promoted 1,4-elimination reaction of N-Boc-1-amino-4-methoxy-2-alkene 1 is shown to proceed with perfect stereoselectivity to afford the corresponding N-Boc-1-amino-1,3-diene 2 in good yields. The reaction is highly stereospecific. The substrate

Copper(II)-acid catalyzed cyclopropanation of 1,3-dienamides by electrophilic activation of α-aryl diazoesters

Copper(II)-acid catalyzed cyclopropanation of electron-rich alkenes, such as 1,3-dienamides, with α-aryl diazoesters are described. The reaction could be performed without rare metal catalysts, excess substrate, or the need for the slow addition of the diazoesters.