1609156-63-9Relevant academic research and scientific papers
Synthesis of 5-arylpyrrolo[2,1-c][1,4]benzodiazepines under mild cyclodehydration conditions
Legerén, Loreto,Domínguez, Domingo
experimental part, p. 2718 - 2722 (2010/05/02)
The efficiency of a cyclodehydration reaction leading to benzodiazepinones is markedly improved by N-methylation of the amide link connecting the nucleophile and the electrophile, which is attributed to its favouring both the more reactive E-rotamer and the exit of the leaving group.
Enantiospecific synthesis of 5-phenylpyrrolo[2,1-c][1,4]benzodiazepines
Legerén, Loreto,Gómez, Eduardo,Domínguez, Domingo
scheme or table, p. 7174 - 7177 (2009/04/10)
Enantiomerically pure 5-phenylpyrrolo[2,1-c][1,4]benzodiazepines were synthesized starting from 2-aminobenzophenones and 2-amino-4-methoxyxanthone, using l-proline as a chiral building block.
