1609192-30-4Relevant academic research and scientific papers
Semi-synthesis of neomangiferin from mangiferin
Wei, Xiong,Liang, Danlin,Ning, Maoheng,Wang, Qing,Meng, Xiangbao,Li, Zhongjun
, p. 3083 - 3086 (2014)
Neomangiferin, a natural xanthone derivative bearing both O- and C-glucosides, was isolated from the leaves of Gentiana asclepiadea L. and has shown potential anti-diabetic activity. We describe herein the first semi-synthesis of neomangiferin from the natural C-glucoside mangiferin and glucose. The developed synthesis presents a facile protection strategy using Jurd's method to distinguish the different phenolic hydroxyl groups. Following this strategy, the regioselective protection of 1,3,6-hydroxyl groups was accomplished and neomangiferin was prepared by glycosylation under the phase-transfer catalysis conditions.
