1609239-20-4Relevant academic research and scientific papers
Synthesis, anti-HIV and cytostatic evaluation of 3′-deoxy-3′- fluorothymidine (FLT) pro-nucleotides
Velanguparackel, Winnie,Hamon, Nadege,Balzarini, Jan,McGuigan, Christopher,Westwell, Andrew D.
, p. 2240 - 2243 (2014)
A series of pro-nucleotide phosphoramidates and phosphorodiamidates of the antiviral lead compound 3′-deoxy-3′-fluorothymidine (FLT) have been designed and synthesized. In vitro antiretroviral and cytostatic studies revealed potent (sub-micromolar) inhibition of HIV-1 and HIV-2 replication, with retention of activity in thymidine kinase-negative cell models, as predicted by the ProTide concept.
