160924-04-9

Basic information

• Product Name: (2R,3S,4S)-2-((S)-1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-4-dibenzylamino-3-hydroxy-5-phenyl-pentanoic acid methyl ester
• CAS NO: 160924-04-9
• Molecular Weight: 622.805
• Mol File: 160924-04-9.mol

Chemical Properties

• CAS DataBase Reference: (2R,3S,4S)-2-((S)-1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-4-dibenzylamino-3-hydroxy-5-phenyl-pentanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S,4S)-2-((S)-1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-4-dibenzylamino-3-hydroxy-5-phenyl-pentanoic acid methyl ester(160924-04-9)
• EPA Substance Registry System: (2R,3S,4S)-2-((S)-1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-4-dibenzylamino-3-hydroxy-5-phenyl-pentanoic acid methyl ester(160924-04-9)

Safety Data

• Hazardous Substances Data: 160924-04-9(Hazardous Substances Data)

Upstream product

• 123054-12-6 (2S)-N,N-dibenzylphenylalaninal 
• 60398-42-7 methyl (3S)-3-{[(tert-butoxy)carbonyl]amino}-4-phenylbutanoate 

Downstream Products

• 160998-86-7 (3R,4S,5S)-5-benzyl-4-hydroxy-3-<1(S)-(1,1-dimethylethoxycarbonylamino)-2-phenyl-ethyl>pyrrolidin-2-one 

Relevant articles and documents

Addition of dilithiated methyl-3-aminobutanoate to aldehydes proceeds with ul-1,2-induction

Syntheses of 2-substituted 1-hydroxyethylene building blocks, useful as the central moiety of HIV-1 protease inhibitors, is described. Dilithiated N-protected-3-amino-4-phenylbutanoic methyl esters are reacted with aldehydes to give predominantly aldol products with l,u configuration. The diastereomeric ratio depends on the N-protecting group and on the experimental conditions. The configurations are assigned by 1H-NMR of cyclic derivatives and are supported by X-ray structure.