1609240-56-3

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 104-87-0 4-methyl-benzaldehyde 
• 1609240-41-6 5,5-dimethyl-2-oxo-4-p-tolyl-2,5-dihydro-1H-chromeno[4,3-b]pyridine-3-carbonitrile 
• 3780-33-4 2,3-dihydro-2,2-dimethylbenzo[b]pyran-4-one 
• 1609240-53-0 6,6-dimethyl-7-p-tolyl-6,10-dihydrochromeno[4,3-b]pyrazolo[4,3-e]pyridin-8-amine 
• 104-88-1 4-chlorobenzaldehyde 
• 1609240-50-7 2-chloro-5,5-dimethyl-4-p-tolyl-5H-chromeno[4,3-b]pyridine-3-carbonitrile 

Relevant academic research and scientific papers

Synthesis of new chromeno[4,3-b]pyrazolo[4,3-e]pyridines derivatives with antimicrobial evaluation

A series of 2-oxo-2,5-dihydro-1H-chromeno[4,3-b]pyridine derivatives were obtained by using a one-pot three component reaction of 2,2-disubstituted chroman-4-one with aromatic aldehydes and 2-cyanoacetamide in the presence of sodium hydroxide under solvent-free conditions. Heating chromenopyridine derivatives with phosphoryl chloride gave the corresponding chloro derivatives. The reaction of the chloro derivatives with hydrazine hydrate afforded dihydrochromeno[4,3-b]pyrazolo[4,3-e]pyridines derivatives. Condensation of the dimethyl derivative compound with the aromatic aldehydes gave 8-Arylideneamino-6,6-dimethyl-10H-chromeno[4,3-b]pyrazolo[4,3-e]pyridine.