1609243-06-2Relevant academic research and scientific papers
One-pot enyne ring-closing metathesis-Diels-Alder reactions for the synthesis of polycyclic sulfamides
Hill-Cousins, Joseph T.,Salim, Sofia S.,Bakar, Youssef M.,Bellingham, Richard K.,Light, Mark E.,Brown, Richard C.D.
, p. 3700 - 3706 (2014/05/20)
Ring-closing metathesis (RCM) and sequential Yb(OTf)3 promoted Diels-Alder reactions of sulfamide-linked enynes proceeded selectively in one-pot to afford a series of bicyclic and tricyclic sulfamides. Excellent levels of diastereoselectivity are observed for the cycloaddition step, with only the endo-adducts being isolated. The protocol was further extended to incorporate a one-pot RCM-cross metathesis (CM)-Diels-Alder sequence, permitting rapid access to high levels of molecular complexity from simple and easily accessible precursors.
