1609244-06-5Relevant academic research and scientific papers
Cu-Catalyzed Arylation/Acyl Migration Cascade Reaction of Enaminones: Access to N-Fused Polycyclic and 2,3-Disubstituted Indoles
Li, Weishuang,Dong, Zhan,Zhang, Yan,Zeng, Zhen,Usman, Muhammad,Liu, Wen-Bo
, p. 7995 - 8005 (2019)
An efficient synthesis of N-fused polycyclic and 2,3-disubstituted indoles by copper-catalyzed direct annulation/acyl migration reaction of enaminones is reported. This strategy features cheap and low loading of the catalyst/ligand, readily available starting materials, and good functional group compatibilities. Notably, allyl-containing substrates are also tolerated, which allows the downstream derivatization toward indole alkaloids.
Synthesis of N-Fused Polycyclic Indoles via Ligand-Free Palladium-Catalyzed Annulation/Acyl Migration Reaction
Dong, Zhan,Zhang, Xiao-Wen,Li, Weishuang,Li, Zi-Meng,Wang, Wen-Yan,Zhang, Yan,Liu, Wei,Liu, Wen-Bo
, p. 1082 - 1086 (2019/02/14)
An efficient synthesis of N-fused polycyclic indoles by a palladium-catalyzed annulation/acyl migration cascade reaction is described. The reaction is ligand-free, scalable, and provides access to a diverse range of useful indole scaffolds from readily available starting materials. Supporting mechanistic studies indicate that the reaction likely proceeds via an intramolecular α-arylation mechanism. The synthetic utility of this protocol is demonstrated by a gram-scale reaction and syntheses toward indole alkaloids and a HSP90 inhibitor.
Dirhodium(II) carboxylate catalyzed formation of 1,2,3-trisubstituted indoles from styryl azides
Jones, Crystalann,Nguyen, Quyen,Driver, Tom G.
, p. 785 - 788 (2014/01/23)
Dirhodium(II)-carboxylate complexes were discovered to promote the selective migration of acyl groups in trisubstituted styryl azides to form 1,2,3-trisubstituted indoles. The styryl azides are readily available in three steps from cyclobutanone and 2-iod
