1609268-39-4Relevant academic research and scientific papers
Urea/thiourea as ammonia surrogate: A catalyst-free synthesis of 2-substituted 2,3-dihydroquinazolin-4(1 H)-ones/quinazoline-4(3 H)-ones
Naidu, P. Paradesi,Raghunadh, Akula,Rao, K. Raghavendra,Mekala, Ramamohan,Babu, J. Moses,Rao,Siddaiah,Pal, Manojit
, p. 1475 - 1482 (2014)
Urea/thiourea have been identified as an effective ammonia surrogate in the construction of quinazolin-4(3H)-one ring. This strategy afforded a simple and catalyst-free synthesis of 2-substituted 2,3-dihydroquinazolin-4(1H)-ones and quinazolin-4(3H)-ones via the reaction of isatoic anhydride and aryl aldehydes in the presence of urea or thiourea in ethanol. The reaction proceeded well to afford the quinazolin-4(3H)-one or its dihydro derivative, depending on the nature of carbonyl compounds employed.
