16093-82-6

Basic information

• Product Name: 1H-Imidazol-2-carboxamide
• Synonyms: 1H-Imidazol-2-carboxamide;1H-Imidazole-2-carboxamide
• CAS NO: 16093-82-6
• Molecular Formula: C₄H₅N₃O
• Molecular Weight: 111.102
• Mol File: 16093-82-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 312-313 °C (decomp)
• Boiling Point: 365.4 °C at 760 mmHg
• Flash Point: 174.8 °C
• Appearance: /
• Density: 1.394 g/cm³
• Vapor Pressure: 1.58E-05mmHg at 25°C
• Refractive Index: 1.612
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.61±0.10(Predicted)
• CAS DataBase Reference: 1H-Imidazol-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazol-2-carboxamide(16093-82-6)
• EPA Substance Registry System: 1H-Imidazol-2-carboxamide(16093-82-6)

Safety Data

• Hazardous Substances Data: 16093-82-6(Hazardous Substances Data)

Usage

General Description

1H-Imidazol-2-carboxamide, also known as imidazole-4-carboxamide or imidazole, is a chemical compound with the molecular formula C3H4N2O. It is a white crystalline solid with a wide range of applications in various industries. Imidazole-4-carboxamide is commonly used as a precursor in the synthesis of pharmaceuticals, such as antifungal and antiparasitic drugs. It also has uses in the production of dyes, photographic chemicals, and agricultural products. Additionally, imidazole-4-carboxamide is a key component in the formulation of many personal care and cosmetic products due to its ability to act as a buffering agent and adjust pH levels. Due to its diverse range of applications, 1H-Imidazol-2-carboxamide is an important and versatile compound in the chemical industry.

InChI:InChI=1/C4H5N3O/c5-3(8)4-6-1-2-7-4/h1-2H,(H2,5,8)(H,6,7)

Upstream product

• 74840-92-9 5H,10H-diimidazo<1,2-a:1',2'-d>pyrazine-5,10-dione dihydrochloride 

Downstream Products

• 31722-49-3 2-cyano imidazole 

Relevant articles and documents

Design, Synthesis, and Biological Evaluation of 2-Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity

Tuberculosis and parasitic diseases, such as giardiasis, amebiasis, leishmaniasis, and trypanosomiasis, all urgently require improved treatment options. Recently, it has been shown that antitubercular bicyclic nitroimidazoles such as pretomanid and delamanid have potential as repurposed therapeutics for the treatment of visceral leishmaniasis. Here, we show that pretomanid also possesses potent activity against Giardia lamblia and Entamoeba histolytica, thus expanding the therapeutic potential of nitroimidazooxazines. Synthetic analogues with a novel nitroimidazopyrazin-one/-e bicyclic nitroimidazole chemotype were designed and synthesized, and structure-activity relationships were generated. Selected derivatives had potent antiparasitic and antitubercular activity while maintaining drug-like properties such as low cytotoxicity, good metabolic stability in liver microsomes and high apparent permeability across Caco-2 cells. The kinetic solubility of the new bicyclic derivatives varied and was found to be a key parameter for future optimization. Taken together, these results suggest that promising subclasses of bicyclic nitroimidazoles containing different core architectures have potential for further development.

PHENYL-3-{ (3- (1H- PYRROL- 2 -YL) - [1 , 2 , 4] 0XADIAZ0L-5-YL] PIPERIDIN-1-YL}-METHANONE DERIVATIVES AND RELATED COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention provides new compounds of formula (I) as positive allosteric modulators of metabotropic receptors - subtype 5 ("mGluR5") which are useful for the treatment or prevention of central nervous system disorders such as for example, cognitive decline, both positive and negative symptoms in schizophrenia as well as other central or peripheral nervous system disorders in which the mGluR5 subtype of glutamate metabotropic receptor is involved. The invention is also directed to pharmaceutical compounds and compositions in the prevention or treatment of such diseases in which mGluKi is involved. W represents (C4-C7)cycloalkyl, (C3-C7)heterocycloalkyl , (C3-C7)heterocycloalkyl-(C1-C3)alkyl or (C3-C7)heterocycloalkenyl ring; represents a (C5-C7)heteroeycloalkyl, (C5-C7)heterocycloalkeiiyl ring or a heteroaryl group of formula (a), (b), (c), (d), (e), (f), (g), (i). Q denotes a cycloalkyl, an aryl or heteroaryl group of formula (j), (k), (l), (m), (n). A is azo -N=N-, ethyl, ethenyl, ethynyl, -NR8C(=O)-, -NR8C(=O)-O-, -NR8C(=O)-NR9, NR8S(=O)2-, -C(=O)NR8-, -O-C(=O)NR8-, -S-, -S(=O)-, -S(=O)2-, -S(C=O)2NR8-, -C(=0)-0-, -0-C(=0)-, -C(=NR8)NR9-, C(C=NOR8)NR9- , -NR8C(=NOR9)-, =N-0-, -0-N=CH- or a group aryl or heteroaryl of formula, (o), (p), (q), (r), (s), (t), (u), (v), (w), (x). The other substituents are defined in the claims.

1 Hydroxyimidazole 3 oxide and some 2 substituted derivatives

-