1609387-12-3

Basic information

• Product Name: (17β)-N-((t-butylcarbamoyl)methyl)-N-(4-methoxyphenyl)-4,4-dimethyl-3-hydroxyandrost-5-ene-17-carboxamide
• Synonyms: (17β)-N-((t-butylcarbamoyl)methyl)-N-(4-methoxyphenyl)-4,4-dimethyl-3-hydroxyandrost-5-ene-17-carboxamide
• CAS NO: 1609387-12-3
• Molecular Weight: 564.809
• Mol File: 1609387-12-3.mol

Chemical Properties

• CAS DataBase Reference: (17β)-N-((t-butylcarbamoyl)methyl)-N-(4-methoxyphenyl)-4,4-dimethyl-3-hydroxyandrost-5-ene-17-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (17β)-N-((t-butylcarbamoyl)methyl)-N-(4-methoxyphenyl)-4,4-dimethyl-3-hydroxyandrost-5-ene-17-carboxamide(1609387-12-3)
• EPA Substance Registry System: (17β)-N-((t-butylcarbamoyl)methyl)-N-(4-methoxyphenyl)-4,4-dimethyl-3-hydroxyandrost-5-ene-17-carboxamide(1609387-12-3)

Safety Data

• Hazardous Substances Data: 1609387-12-3(Hazardous Substances Data)

Upstream product

• 1255359-09-1 (17β)-4,4-dimethyl-3-oxoandrost-5-ene-17-carboxylic acid 
• 1609387-15-6 (17β)-N-((t-butylcarbamoyl)methyl)-N-(4-methoxyphenyl)-4,4-dimethyl-3-oxoandrost-5-ene-17-carboxamide 
• 1609387-14-5 C₂₃H₃₄O₃ 
• 2681-55-2 3-oxo-androst-4-ene-17β-carboxylic acid methyl ester 

Relevant articles and documents

Multicomponent synthesis of 4,4-dimethyl sterol analogues and their effect on eukaryotic cells

Most sterols, such as cholesterol and ergosterol, become functional only after the removal of the two methyl groups at C-4 from their biosynthetic precursors. Nevertheless, some findings suggest that 4,4-dimethyl sterols might be involved in specific physiological processes. In this paper we present the synthesis of a collection of analogues of 4,4-dimethyl sterols with a diamide side chain and a preliminary analysis of their in vitro activity on selected biological systems. The key step for the synthesis involves an Ugi condensation, a versatile multicomponent reaction. Some of the new compounds showed antifungal and cytotoxic activity.