1609387-28-1Relevant articles and documents
Multicomponent synthesis of 4,4-dimethyl sterol analogues and their effect on eukaryotic cells
Alonso, Fernando,Cirigliano, Adriana M.,Dávola, María Eugenia,Cabrera, Gabriela M.,García Li?ares, Guadalupe E.,Labriola, Carlos,Barquero, Andrea A.,Ramírez, Javier A.
, p. 1 - 6 (2014/04/03)
Most sterols, such as cholesterol and ergosterol, become functional only after the removal of the two methyl groups at C-4 from their biosynthetic precursors. Nevertheless, some findings suggest that 4,4-dimethyl sterols might be involved in specific physiological processes. In this paper we present the synthesis of a collection of analogues of 4,4-dimethyl sterols with a diamide side chain and a preliminary analysis of their in vitro activity on selected biological systems. The key step for the synthesis involves an Ugi condensation, a versatile multicomponent reaction. Some of the new compounds showed antifungal and cytotoxic activity.