1609451-25-3Relevant academic research and scientific papers
Catalytic cycle for palladium-catalyzed decarbonylative trifluoromethylation using trifluoroacetic esters as the CF3 source
Maleckis, Ansis,Sanford, Melanie S.
, p. 2653 - 2660 (2014/06/10)
This paper demonstrates a catalytic cycle for Pd-catalyzed decarbonylative trifluoromethylation using trifluoroacetic esters as CF3 sources. The proposed cycle consists of four elementary steps: (1) oxidative addition of a trifluoroacetic ester to Pd0, (2) CO deinsertion from the resulting trifluoroacyl PdII complex, (3) transmetalation of a zinc aryl to PdII, and (4) aryl-CF3 bond-forming reductive elimination. The use of RuPhos as the supporting ligand enables each of these steps to proceed under mild conditions (3 sources.
