1609460-40-3

Upstream product

• 40447-04-9 N-(3-chloro-2-methylphenyl)benzamide 
• 31376-45-1 N-(3-Chlor-2-methylphenyl)benzimidchlorid 
• 100-46-9 benzylamine 
• 93-98-1 N-phenyl benzoyl amide 

Downstream Products

• 1609460-23-2 7-chloro-8-methyl-2,4-diphenylquinazoline 
• 1609460-56-1 1-benzyl-5-chloro-4-methyl-2-phenyl-1H-benzo[d]imidazole 

Relevant academic research and scientific papers

Solvent/oxidant-switchable synthesis of multisubstituted quinazolines and benzimidazoles via metal-free selective oxidative annulation of arylamidines

A fast and simple divergent synthesis of multisubstituted quinazolines and benzimidazoles was developed from readily available amidines, via iodine(III)-promoted oxidative C(sp3)-C(sp2) and C(sp 2)-N bond formation in nonpolar and polar solvents, respectively. Further selective synthesis of quinazolines in polar solvent was realized by TEMPO-catalyzed sp3C-H/sp2C-H direct coupling of the amidine with K2S2O8 as the oxidant. No metal, base, or other additives were needed.