1609461-70-2Relevant academic research and scientific papers
Inhibition of biofilm formation by conformationally constrained indole-based analogues of the marine alkaloid oroidin
Hodnik, Ziga,Los, Joanna M.,Zula, Ales,Zidar, Nace,Jakopin, Ziga,Los, Marcin,Sollner Dolenc, Marija,Ilas, Janez,Wegrzyn, Grzegorz,Peterlin Masic, Lucija,Kikelj, Danijel
, p. 2530 - 2534 (2014)
Herein, we describe indole-based analogues of oroidin as a novel class of 2-aminoimidazole-based inhibitors of methicillin-resistant Staphylococcus aureus biofilm formation and, to the best of our knowledge, the first reported 2-aminoimidazole-based inhibitors of Streptococcus mutans biofilm formation. This study highlighted the indole moiety as a dibromopyrrole mimetic for obtaining inhibitors of S. aureus and S. mutans biofilm formation. The most potent compound in the series, 5-(trifluoromethoxy)indole-based analogue 4b (MBIC50 = 20 μM), emerged as a promising hit for further optimisation of novel inhibitors of S. aureus and S. mutans biofilms.
