1609462-75-0Relevant academic research and scientific papers
One-pot cross-enyne metathesis (CEYM)-Diels-Alder reaction of gem-difluoropropargylic alkynes
Fustero, Santos,Bello, Paula,Miro, Javier,Sanchez-Rosello, Maria,Haufe, Guenter,Del Pozo, Carlos
, p. 2688 - 2695 (2014/01/06)
Propargylic difluorides 1 were used as starting substrates in a combination of cross-enyne metathesis and Diels-Alder reactions. Thus, the reaction of 1 with ethylene in the presence of 2nd generation Hoveyda-Grubbs catalyst generates a diene moiety which in situ reacts with a wide variety of dienophiles giving rise to a small family of new fluorinated carbo- and heterocyclic derivatives in moderate to good yields. This is a complementary protocol to the one previously described by our research group, which involved the use of 1,7-octadiene as an internal source of ethylene.
