1609488-36-9Relevant academic research and scientific papers
Asymmetric reduction of imines with trichlorosilane catalyzed by valine-derived formamide immobilized onto magnetic nano-Fe3O4
Ge, Xin,Qian, Chao,Ye, Xiaoming,Chen, Xinzhi
, p. 65402 - 65407 (2015)
Magnetic nano-Fe3O4-supported organocatalysts were synthesized by anchoring valine-derived formamide onto the surface of Fe3O4 magnetic nanoparticles, which were applied in the asymmetric reduction of imines wit
Novel carbohydrate-derived pyridinecarboxylic organocatalysts for the enantioselective reduction of imines with trichlorosilane
Ge, Xin,Qian, Chao,Chen, Yunbin,Chen, Xinzhi
, p. 596 - 601 (2014/05/20)
A new type of carbohydrate-derived pyridinecarboxylic organocatalyst was prepared by fine-tuning a d-glucosamine backbone at the C-2 and C-3 positions. The carbohydrate-derived pyridinecarboxylic organocatalyst was used for the enantioselective reduction of imines with trichlorosilane. The reduction proceeded in high yield (up to 93%) and with moderate enantioselectivity (up to 75%).
Synthesis of novel carbohydrate-based valine-derived formamide organocatalysts by CuAAC click chemistry and their application in asymmetric reduction of imines with trichlorosilane
Ge, Xin,Qian, Chao,Chen, Xinzhi
, p. 1450 - 1455 (2015/01/08)
Novel organocatalysts combining carbohydrate and N-formyl-l-valine derivatives were prepared by CuII-catalyzed diazo transfer and CuI-catalyzed azide-alkyne 1,3-dipolar cycloaddition CuAAC click chemistry. It was found that the carbohydrate-based valine-derived formamide organocatalyst had high catalytic activity for the asymmetric reduction of imines with trichlorosilane. The reduction can proceed at room temperature in toluene in high yield (up to 98%) and with excellent enantioselectivity (up to 94%). 'CuAAC' click chemistry is a bridge to link N-formyl-l-valine derived organocatalysts with carbohydrates.
