16095-40-2

Upstream product

• 118-91-2 ortho-chlorobenzoic acid 
• 106-47-8 4-chloro-aniline 
• 50-00-0 formaldehyd 
• 13278-35-8 2-(4-chloroanilino)benzoic acid 

Downstream Products

• 16075-15-3 1-(4-chloro-phenyl)-1,2-dihydro-benzo[d][1,3]thiazin-4-one 
• 16074-97-8 1-(4-chloro-phenyl)-1,2-dihydro-benzo[d][1,3]thiazine-4-thione 
• 16075-04-0 1-(4-chloro-phenyl)-1,2-dihydro-benzo[d][1,3]oxazine-4-thione 

Relevant academic research and scientific papers

A process for preparing 1, 2 - dihydro - (4 H) - 3, 1 - benzoxazin -4 - ketone compound method

The invention discloses a method for utilizing N - methyl - N - aryl anthranilic acid compound synthesis of 1, 2 - dihydro - (4 H) - 3, 1 - benzoxazin - 4 - ketone compounds, the synthetic method is: the palladium salt as a catalyst, the N - methyl - N -

Pd-Catalyzed Intramolecular Chemoselective C(sp2)-H and C(sp3)-H Activation of N-Alkyl- N-arylanthranilic Acids

A controllable palladium-catalyzed intramolecular C-H activation of N-alkyl-N-arylanthranilic acids has been developed. The methodology allows selective synthesis of 1,2-dihydro-(4H)-3,1-benzoxazin-4-ones and carbazoles from the same starting materials and palladium catalyst. The selectivity is controlled by the oxidant. Silver oxide promotes C(sp3)-H activation/C-O cyclization to provide 1,2-dihydro-(4H)-3,1-benzoxazin-4-ones, while copper acetate contributes to C(sp2)-H activation/decarboxylative arylation to afford carbazoles. This protocol is demonstrated by its wide substrate scope and good functional group tolerance.