1609542-99-5Relevant articles and documents
Direct C-2 acylation of thiazoles with aldehydes via metal- and solvent-free c-h activation in the presence of tert-butyl hydroperoxide
Khemnar, Ashok B.,Bhanage, Bhalchandra M.
, p. 110 - 114 (2014)
A novel and efficient methodology for the synthesis of heteroaryl ketones by C-H activation of aldehydes and thiazoles is developed. The reaction occurs smoothly, under metal-, acid- and solvent-free conditions using tert-butyl hydroperoxide as the oxidant under an air atmosphere, to afford a wide range of heteroaryl ketones in moderate to good yields. The sp2 C-H bonds in the aldehyde and thiazole undergo direct oxidative cross-coupling, resulting in C-2 acylation of the azole. Georg Thieme Verlag Stuttgart · New York.
