1609547-18-3Relevant academic research and scientific papers
Simple assembly of polysubstituted pyrazoles and isoxazoles via ring closure-ring opening domino reaction of 3-acyl-4,5-dihydrofurans with hydrazines and hydroxylamine
Chagarovskiy, Alexey O.,Budynina, Ekaterina M.,Ivanova, Olga A.,Rybakov, Victor B.,Trushkov, Igor V.,Melnikov, Mikhail Ya.
, p. 2905 - 2915 (2016/03/12)
A convenient general approach to 2-(pyrazol-4-yl)- and 2-(isoxazol-4-yl)ethanols based on the Br?nsted acid-initiated reaction of 3-acyl-4,5-dihydrofurans with hydrazines or hydroxylamine was developed. Further transformation of the alcohol moiety in 2-(pyrazolyl)ethanols affording 2-(pyrazolyl)ethylamine as potent bioactive compounds as well as pyrazole-substituted derivatives of antitumor alkaloid crispine A was elaborated.
Reaction of Corey ylide with α,β-Unsaturated Ketones: Tuning of Chemoselectivity toward Dihydrofuran Synthesis
Chagarovsky, Alexey O.,Budynina, Ekaterina M.,Ivanova, Olga A.,Villemson, Elena V.,Rybakov, Victor B.,Trushkov, Igor V.,Melnikov, Mikhail Ya.
supporting information, p. 2830 - 2833 (2014/06/23)
A straightforward, efficient, and reliable approach to synthetically valuable 2,3-dihydrofurans via a reaction between Corey ylide and α,β-unsaturated ketones has been developed. The use of simple and widely spread starting materials as well as mild reaction conditions and scalability provide a broad scope of 2,3-dihydrofurans.
