1609548-88-0Relevant academic research and scientific papers
Iron(II)-catalyzed intramolecular olefin aminofluorination
Lu, Deng-Fu,Liu, Guan-Sai,Zhu, Cheng-Liang,Yuan, Bo,Xu, Hao
, p. 2912 - 2915 (2014)
An iron(II)-catalyzed diastereoselective olefin aminofluorination is reported (dr up to >20:1). This new transformation applies a functionalized hydroxylamine and Et3N·3HF as the nitrogen and fluorine source, which facilitates the efficient synthesis of β-fluoro primary amines and amino acids from allylic alcohol derivatives. Preliminary mechanistic studies reveal that an iron-nitrenoid is a possible intermediate and that its reactivity and enantioselectivity can be efficiently modulated by ligands.
