1609552-01-3Relevant academic research and scientific papers
1, 3, 4- [...] and isothiazolinone acetyl amine derivatives and its synthetic method
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Paragraph 0026; 0027; 0028; 0029, (2017/02/17)
The invention relates to a 1,3,4-thiadiazole benzisothiazolinone acetamide derivative and a synthesis method thereof. The 1,3,4-thiadiazole benzisothiazolinone acetamide derivative has a structural formula shown in a drawing, wherein R is hydrogen, 3-methyl, 4-methoxy, 4-chloro or 2-bromo-4-nitro. The synthesis method comprises the steps of dissolving substituted 2-amino-5-substituted phenyl-1,3,4-thiadiazole and benzisothiazolin-3-one-2-yl acetic acid with an organic solvent, adding a condensing agent, reacting for 16-24 hours at the temperature of 10-30 DEG C, pouring a solution into water after the reaction is completed, and precipitating solids; filtrating, washing, drying, and then carrying out column chromatography, thereby obtaining the 1,3,4-thiadiazole benzisothiazolinone acetamide derivative which has good biological activity. According to the 1,3,4-thiadiazole benzisothiazolinone acetamide derivative and the synthesis method thereof, the reaction conditions are mild, the reacting operation is simple and convenient, and the reaction yield is relatively high.
Synthesis of N-(5-aryl-1,3,4-thiadiazol-2-yl)-2-(3-oxo-1,2-benzothiazol- 2(3H)-yl)acetamide derivatives promoted by carbodiimide condensation
Yu, Peng,Hu, Jun,Wan, Rong,Li, Xi,Zheng, Shanlong,Xu, Yanhua
, p. 347 - 350 (2014/07/08)
Novel N-(5-aryl-1,3,4-thiadiazol-2-yl)-2-(3-oxo-1,2-benzothiazol-2(3H)-yl) acetamide derivatives were prepared by 1-(3-dimethylaminopropyl)-3- ethylcarbodiimide hydrochloride and N-hydroxybenzotrizole condensation catalysis in a convenient and fast method
