1609566-35-9Relevant academic research and scientific papers
Ultrasound irradiation promotes the synthesis of new 1,2,4-triazolo[1,5-a] pyrimidine
Frizzo, Clarissa P.,Scapin, Elisandra,Marzari, Mara R.B.,München, Taiana S.,Zanatta, Nilo,Bonacorso, Helio G.,Buriol, Lilian,Martins, Marcos A.P.
, p. 958 - 962 (2014/02/14)
Ultrasonic irradiation was used in the synthesis of a series of novel 1,2,4-triazolo[1,5-a]pyrimidines. The products were synthetized from the cyclocondensation reaction of 1,1,1-trifluoro-4-metoxy-3-alken-2-one [CF 3C(O)CHC(R)OMe, where R = Ph, 4-F-C6H4, 4-Br-C6H4, 4-I-C6H4, 4-CH 3-C6H4, 4-CH3O-C6H 4, Thien-2-yl, Biphen-4-yl] or β-enaminones [RC(O)CHCHNMe 2, where R = Ph, 4-F-C6H4, 4-Br-C 6H4, 4-I-C6H4, 4-CH 3-C6H4, 4-CH3O-C6H 4, 4-NO2-C6H4, Thien-2-yl, Biphen-4-yl, Naphth-2-yl, Pyrrol-2-yl, CCl3] with 5-amino-1,2,4-triazole in acetic acid at 99 C with 5-17 min of ultrasound irradiation. This methodology has shown several advantages, such as shorter reaction times, mild conditions, high regioselectivity, and excellent yields, when compared with conventional thermal heating (oil bath).
