1609583-45-0

Basic information

• Product Name: 8-methyl-2-phenyl-3-(phenylthio)-1H-imidazo[1,2-a]pyridine
• Synonyms: 8-methyl-2-phenyl-3-(phenylthio)-1H-imidazo[1,2-a]pyridine
• CAS NO: 1609583-45-0
• Molecular Weight: 316.426
• Mol File: 1609583-45-0.mol

Chemical Properties

• CAS DataBase Reference: 8-methyl-2-phenyl-3-(phenylthio)-1H-imidazo[1,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-methyl-2-phenyl-3-(phenylthio)-1H-imidazo[1,2-a]pyridine(1609583-45-0)
• EPA Substance Registry System: 8-methyl-2-phenyl-3-(phenylthio)-1H-imidazo[1,2-a]pyridine(1609583-45-0)

Safety Data

• Hazardous Substances Data: 1609583-45-0(Hazardous Substances Data)

Upstream product

• 1603-40-3 3-methylpyridin-2-ylamine 
• 70-11-1 α-bromoacetophenone 
• 591-50-4 iodobenzene 
• 885-89-2 8-methyl-2-phenylimidazo[1,2-a]pyridine 
• 873-55-2 sodium benzenesulfonate 
• 80-17-1 benzenesufonyl hydrazide 
• 108-98-5 thiophenol 
• 98-80-6 phenylboronic acid 

Relevant articles and documents

Iodine-catalyzed regioselective thiolation of imidazo[1,2-a]pyridines using sulfonyl hydrazides as a thiol surrogate

Iodine-catalyzed regioselective sulfenylation of imidazo[1,2-a]pyridines via C(sp2)-H bond functionalization has been achieved using sulfonyl hydrazides as a thiol surrogate. A library of 3-sulfanylimidazopyridines with broad functionalities was synthesized under metal and oxidant-free practical reaction conditions. This methodology is also applicable for the regioselective sulfenylation of imidazo[2,1-b]thiazole and benzo[d]imidazo[2,1-b]thiazole. This journal is

Unconventional Reactivity with DABCO-Bis(sulfur dioxide): C–H Bond Sulfenylation of Imidazopyridines

This work highlights the unexpected and unprecedented outcome of the reactivity with DABCO-bis(sulfur dioxide). The use of this reagent led to the exclusive introduction of a sulfur atom on the C-3 position of imidazopyridines instead of a sulfone group.

Iodine-Mediated Difunctionalization of Imidazopyridines with Sodium Sulfinates: Synthesis of Sulfones and Sulfides

Novel iodine-induced sulfonylation and sulfenylation of imidazopyridines have been described using sodium sulfinates as the sulfur source. This strategy enables highly selective difunctionalization of imidazo[1,2-a]pyridine to access sulfones and sulfides in good yields. A wide range of substrates and functional groups were well-tolerated under optimized conditions. Moreover, control experiments have been conducted, indicating a radical pathway involved in the reaction mechanisms.

Copper-catalyzed three-component reaction of imidazo[1,2-a]pyridine with elemental sulfur and arylboronic acid to produce sulfenylimidazo[1,2-a]pyridines

In this work, an efficient copper-catalyzed three-component reaction for the synthesis of sulfenylimidazo[1,2-a]pyridines using elemental sulfur as the sulfenylating agents has been developed. The reaction could proceed smoothly with a high degree of functional group tolerance and provide the desired products in moderate to good yield.

Iodine-triphenylphosphine mediated sulfenylation of imidazoheterocycles with sodium sulfinates

An efficient approach to sulfenyl imidazoheterocycles has been developed via iodine-triphenylphosphine mediated direct sulfenylation of imidazoheterocycles with sodium sulfinates. The reactions proceed smoothly under transition-metal-free conditions with a broad range of substrate scope, giving the desired products in moderate to excellent yields. This journal is

N-chlorosuccinimide-promoted regioselective sulfenylation of imidazoheterocycles at room temperature

Regioselective sulfenylation of imidazoheterocycles with thiophenols at room temperature is reported. Sulfenylation is promoted by N-chlorosuccinimide under metal-free conditions with a broad range of substrate scopes.