1609636-75-0Relevant academic research and scientific papers
Synthesis of hexahydropyrazino[1,2-b]isoquinolines as simplified saframycin analogues
Nguyen Van, Tuyen,Claes, Pieter,De Kimpe, Norbert
, p. 69 - 74 (2014)
Various hexahydropyrazino[1,2-b]isoquinolines were synthesised as simplified saframycin analogues. Construction of this core proceeded through a tetrahydroisoquinoline synthesis followed by acylation/alkylation of the tetrahydroisoquinoline nitrogen and subsequent ring closure using various aliphatic and aromatic amines. The resulting piperazinones were reacted with LiAlH4 or LiAlH(OEt)3 to synthesise further analogues. Georg Thieme Verlag Stuttgart · New York.
