1609650-30-7

Upstream product

• 15014-25-2 malonic acid dibenzyl ester 
• 1794-48-5 1-bromo-3-phenylprop-2-yne 
• 1504-58-1 3-Phenyl-2-propyn-1-ol 
• 536-74-3 phenylacetylene 
• 21541-60-6 3-phenylprop-2-ynyl 4-methylbenzenesulfonate 

Downstream Products

• 1609650-45-4 (4,4-bis(benzyloxymethyl)-6-methylhept-6-en-1-ynyl)benzene 
• 1609650-31-8 2-(2-methylallyl)-2-(3-phenylprop-2-ynyl)malonic acid dibenzyl ester 
• 1609650-42-1 2-(2-methylenebutyl)-2-(3-phenylprop-2-ynyl)malonic acid dibenzyl ester 

Relevant academic research and scientific papers

Iron-Catalyzed [2+2+2] Annulation of Aliphatic Bridged 1,n-Enynes with Aldehydes for the Synthesis of Fused Pyrans

An iron-catalyzed [2+2+2] annulation of aliphatic bridged 1,n-enynes with aldehydes was developed. Aldehydes play a dual role as the precursors of acyl radicals to trigger the cascade cyclization but also as the radical acceptors to terminate the annulation. This two-in-one strategy overcomes the limitation in [2+2+m] cyclization that requires a rigid benzene skeleton as the essential linker, thus enabling the efficient synthesis of functionalized fused [5.6] and [6.6] pyran skeletons.

Enantioselective cycloisomerization of 1,6-enynes to bicyclo[3.1.0]hexanes catalyzed by rhodium and benzoic acid

It has been established that a cationic Rh(I)/(S)-Segphos or (S)-DTBM-Segphos complex and benzoic acid catalyze the enantioselective cycloisomerization of 1,6-enynes, possessing carbonyl groups at the enyne linkage, to 2-alkylidenebicyclo[3.1.0]hexanes. The present cycloisomerization may involve site selective γ-hydrogen elimination. The one-pot enantioselective cycloisomerization and lactonization of 1,6-enynes, leading to bicyclic lactones, has also been accomplished.