1609653-22-6Relevant academic research and scientific papers
Copper-Promoted Intramolecular Aminotrifluoromethylation of Alkenes with Langlois Reagent as the Trifluoromethyl Source
Zhang, Hong-Yu,Huo, Wenge,Ge, Chao,Zhao, Jiquan,Zhang, Yuecheng
, p. 962 - 965 (2017)
A novel approach for copper-promoted intramolecular aminotrifluoromethylation of alkenes using inexpensive CF3SO2Na as the trifluoromethyl source is described. The feature of this method is the concurrent construction of a five-membered ring and a C-CF3 bond in the simple copper salt/TBHP system. A gram-scale reaction was tested with a slight decrease in the yield. This protocol provides an operationally simple, step-economical and synthetically useful access to a variety of trifluoromethyl indolines, pyrrolidines and lactams.
Efficient copper-catalyzed direct intramolecular aminotrifluoromethylation of unactivated alkenes with diverse nitrogen-based nucleophiles
Lin, Jin-Shun,Xiong, Ya-Ping,Ma, Can-Liang,Zhao, Li-Jiao,Tan, Bin,Liu, Xin-Yuan
, p. 1332 - 1340 (2014/04/03)
A mild, convenient, and step-economical intramolecular aminotrifluoromethylation of unactivated alkenes with a variety of electronically distinct, nitrogen-based nucleophiles in the presence of a simple copper salt catalyst, in the absence of extra ligand
