1609659-22-4

Upstream product

• 1609659-21-3 C₂₂H₂₇BrN₂O₂S 
• 73183-34-3 bis(pinacol)diborane 
• 14395-53-0 2-bromo-4-methylbenzenethiol 
• 1609659-20-2 tert-butyl 4-(2-iodophenyl)piperazine-1-carboxylate 

Downstream Products

• 1620386-92-6 C₂₃H₃₁BN₂O₂S 

Relevant academic research and scientific papers

11C-labeling and preliminary evaluation of vortioxetine as a PET radioligand

Vortioxetine is a new multi-modal drug against major depressive disorder with high affinity for a range of different serotonergic targets in the CNS. We report the 11C-labeling of vortioxetine with [11C]MeI using a Suzuki-protocol that allows for the presence of an unprotected amine. Preliminary evaluation of [11C]vortioxetine in a Danish Landrace pig showed rapid brain uptake and brain distribution in accordance with the pharmacological profile, all though an unexpected high binding in cerebellum was also observed. [11C]vortioxetine displayed slow tracer kinetics with peak uptake after 60 min and with limited wash-out from the brain. Further studies are needed but this radioligand may prove to be a valuable tool in unraveling the clinical effects of vortioxetine.