1609669-84-2

Upstream product

• 1609669-79-5 C₁₃H₁₇N₂O₄P 
• 77-78-1 dimethyl sulfate 
• 54132-82-0 C₉H₁₆O₆P^(1-)*Na⁽¹⁺⁾ 
• 59-88-1 phenylhydrazine hydrochloride 

Downstream Products

• 1609669-89-7 diethyl (1-methyl-3-oxo-2-phenylpyrazolidin-4-yl)phosphonate 
• 1609669-54-6 1-methyl-4-methylene-2-phenylpyrazolidin-3-one 

Relevant academic research and scientific papers

Design, synthesis and cytotoxic evaluation of 4-methylidenepyrazolidin-3-ones

Three series of new 4-methylidenepyrazolidin-3-ones with various substitution patterns were synthesized and tested for the cytotoxic activity against two human leukemia cell lines NALM-6 and HL-60 as well as MCF-7 breast cancer cell line. Several obtained

Versatile synthesis of 4-methylidenepyrazolidin-3-ones using a Horner-Wadsworth-Emmons approach

A new, versatile method for the synthesis of, so far unknown, variously substituted 4-methylidenepyrazolidin-3-ones as potential cytotoxic agents is described. Target compounds were synthesized from the corresponding 4-diethoxyphosphorylpyrazolidin-3-ones which were used as Horner-Wadsworth- Emmons -reagents for the olefination of formaldehyde. 4-Phosphorylpyrazolidin-3- ones were, in turn, obtained starting from the sodium salt of ethyl 2-diethoxyphosphoryl-3-hydroxy-2-propenoate, ethyl 2-acyl-2- diethoxyphosphorylacetates, or 3-methoxy-2-diethoxyphosphorylacrylate and monosubstituted or 1,2-disubstituted hydrazines. Georg Thieme Verlag Stuttgart · New York.