160969-00-6

Basic information

• Product Name: 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl bromide
• Synonyms: 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl bromide;1-(2-Bromo-ethoxy)-2-(2,2,2,trifluro ethoxy)benzene;Silodosin InterMediate;1-(2-BroMoethoxy)-2-(2,2,2-trifluoroethoxy)benzene
• CAS NO: 160969-00-6
• Molecular Formula: C₁₀H₁₀BrF₃O₂
• Molecular Weight: 299.085
• EINECS: 1312995-182-4
• Mol File: 160969-00-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 273.6 °C at 760 mmHg
• Flash Point: 148 °C
• Appearance: cream
• Density: 1.495
• Vapor Pressure: 0.00948mmHg at 25°C
• Refractive Index: 1.482
• CAS DataBase Reference: 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl bromide(160969-00-6)
• EPA Substance Registry System: 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl bromide(160969-00-6)

Safety Data

• Hazardous Substances Data: 160969-00-6(Hazardous Substances Data)

Usage

General Description

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl bromide is a chemical compound with the formula C10H11BrF3O2. It is a brominated derivative of 2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethanol, and is used as a reagent in organic synthesis. 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl bromide has potential use in medicinal chemistry due to its ability to interact with biological molecules, specifically in designing new therapeutic agents or as a building block for various pharmaceutical compounds. However, it is important to handle and use this chemical with caution, as it is a reactive and potentially hazardous substance.

InChI:InChI=1/C10H10BrF3O2/c11-5-6-15-8-3-1-2-4-9(8)16-7-10(12,13)14/h1-4H,5-7H2

Upstream product

• 353-83-3 1,1,1-trifluoro-2-iodoethane 
• 90-05-1 2-methoxy-phenol 
• 160968-99-0 2-O-(2,2,2-trifluoroethyl)catechol 
• 106-93-4 ethylene dibromide 
• 106854-74-4 2-methoxy-1-(2,2,2-trifluoroethoxy)benzene 

Downstream Products

• 175837-07-7 1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile 
• 1031281-18-1 (-)-2-Methoxy-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]benzenesulfonamide 
• 1423218-40-9 tert-butyl (2R)-(1-(1-(3-benzyloxypropyl)-7-cyanoindolin-5-yl)propane-2-yl)-N-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate 

Relevant articles and documents

Synthesis and pharmacological evaluation of novel silodosin-based arylsulfonamide derivatives as α1A/α1D-adrenergic receptor antagonist with potential uroselective profile

Benign prostatic hyperplasia (BPH) is the most common male clinical problem impacting the quality of life of older men. Clinical studies have indicated that the inhibition of α1A-/α1D adrenoceptors might offer effective therapy in lower urinary tract symptoms. Herein, a limited series of arylsulfonamide derivatives of (aryloxy)ethyl alicyclic amines was designed, synthesized, and biologically evaluated as potent α1-adrenoceptor antagonists with uroselective profile. Among them, compound 9 (3-chloro-2-fluoro-N-([1-(2-(2-(2,2,2-trifluoroethoxy)phenoxy]ethyl)piperidin-4-yl) methyl) benzenesulfonamide) behaved as an α1A-/α1D-adrenoceptor antagonist (Ki(α1) = 50 nM, EC50(α1A) = 0.8 nM, EC50(α1D) = 1.1 nM), displayed selectivity over α2-adrenoceptors (Ki(α2) = 858 nM), and a 5-fold functional preference over the α1B subtype. Compound 9 showed adequate metabolic stability in rat-liver microsome assay similar to the reference drug tamsulosin (Clint = 67 and 41 μL/min/mg, respectively). Compound 9 did not decrease systolic and diastolic blood pressure in normotensive anesthetized rats in the dose of 2 mg/kg, i.v. These data support development of uroselective agents in the group of arylsulfonamides of alicyclic amines with potential efficacy in the treatment of lower urinary tract symptoms associated to benign prostatic hyperplasia.