16097-63-5

Usage

Chemical Properties

Colorless liquid

InChI:InChI=1/C6H4ClF3N2S/c1-13-5-11-3(6(8,9)10)2-4(7)12-5/h2H,1H3

Upstream product

• 368-54-7 6-trifluoromethyl-4-hydroxy-2-mercaptopyrimidine 
• 1122-74-3 4-iodo-2-(methylthio)pyrimidine 
• 136547-20-1 2-(methylthio)-4-(trifluoromethyl)pyrimidine 
• 16097-62-4 4-hydroxy-2-(methylthio)-6-(trifluoromethyl)pyrimidine 

Downstream Products

• 93669-61-5 4-N-Methylanilino-2-methylthio-6-trifluoromethylpyrimidine 
• 85730-33-2 4-methoxy-2-(methylsulfanyl)-6-(trifluoromethyl)pyrimidine 
• 85730-32-1 4-Amino-2-methylthio-6-trifluoromethylpyrimidine 
• 342651-54-1 2-(methylthio)-4-[4-(methylthio)phenyl]-6-(trifluoromethyl) pyrimidine 
• 175836-64-3 2-methylthio-4-trifluoromethyl-6-[3-(trifluoromethyl)phenoxy]pyrimidine 
• 1186423-68-6 4-[2-(butylamino)-6-(trifluoromethyl)pyrimidin-4-yl]benzenesulfonamide 

Relevant academic research and scientific papers

PYRIMIDINE AND FIVE-MEMBERED NITROGEN HETEROCYCLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USES THEREOF

The present invention relates to a pyrimidine and a five-membered nitrogen heterocycle derivative, a preparation method therefor, and the medical uses thereof. Particularly, the present invention relates to a pyrimidine and a five-membered nitrogen hetero

APOPTOSIS INHIBITORS

The invention provides compounds that are inhibitors or covalent modifiers of succinate dehydrogenase subunit B (SDHB) and/or inhibitors of apoptosis, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition.

Discovery of Highly Potent 2-Sulfonyl-Pyrimidinyl Derivatives for Apoptosis Inhibition and Ischemia Treatment

A series of 2-sulfonyl-pyrimidinyl derivatives was developed as apoptosis inhibitors. These represent the first class of apoptosis inhibitors that function through stabilizing mitochondrial respiratory complex II. Starting from a phenotypic screen hit with micromolar activity, we optimized the cellular apoptosis inhibition activity of 2-sulfonyl-pyrimidinyl derivatives to picomolar level (compound 42, also named as TC9-305). The therapeutic potential of these new apoptosis inhibitors was further demonstrated by their neuroprotective effect on an ischemic animal model.

PYRIMIDINE COMPOUND AND ITS USE IN PEST CONTROL

A pyrimidine compound represented by below formula (I) has excellent control activity against pests and is useful as an active ingredient of a pest controlling agent.

Synthesis and Metalation of Trifluoromethylpyrimidines. Metalation of Diazines. XVI

A new route to trifluoromethylpyrimidines is described.Lithiation of trifluoromethylpyrimidines was successfully achieved and was used to synthesize new pyrimidine derivatives.A new synthetic route to a biologically active molecule with antimycotic activi