16097-63-5Relevant articles and documents
PYRIMIDINE AND FIVE-MEMBERED NITROGEN HETEROCYCLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USES THEREOF
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Paragraph 0140; 0141, (2021/10/07)
The present invention relates to a pyrimidine and a five-membered nitrogen heterocycle derivative, a preparation method therefor, and the medical uses thereof. Particularly, the present invention relates to a pyrimidine and a five-membered nitrogen hetero
Discovery of Highly Potent 2-Sulfonyl-Pyrimidinyl Derivatives for Apoptosis Inhibition and Ischemia Treatment
Li, Li,Jiang, Xian,Huang, Shaoqiang,Ying, Zhengxin,Zhang, Zhaolan,Pan, Chenjie,Li, Sisi,Wang, Xiaodong,Zhang, Zhiyuan
supporting information, p. 407 - 412 (2017/04/21)
A series of 2-sulfonyl-pyrimidinyl derivatives was developed as apoptosis inhibitors. These represent the first class of apoptosis inhibitors that function through stabilizing mitochondrial respiratory complex II. Starting from a phenotypic screen hit with micromolar activity, we optimized the cellular apoptosis inhibition activity of 2-sulfonyl-pyrimidinyl derivatives to picomolar level (compound 42, also named as TC9-305). The therapeutic potential of these new apoptosis inhibitors was further demonstrated by their neuroprotective effect on an ischemic animal model.
Synthesis and Metalation of Trifluoromethylpyrimidines. Metalation of Diazines. XVI
Ple, N.,Turck, A.,Heynderickx, A.,Queguiner, G.
, p. 551 - 556 (2007/10/03)
A new route to trifluoromethylpyrimidines is described.Lithiation of trifluoromethylpyrimidines was successfully achieved and was used to synthesize new pyrimidine derivatives.A new synthetic route to a biologically active molecule with antimycotic activi
