1609929-64-7Relevant academic research and scientific papers
A facile method for building fused quinoxaline-quinolinones via an acidless post-Ugi cascade reaction
Li, Yong,Lei, Jie,Xu, Jia,Tang, Dian-Yong,Chen, Zhong-Zhu,Zhu, Jin,Xu, Chuan
, p. 541 - 545 (2017)
A series of quinolino[3,4-b]quinoxalin-6(5H)-ones have been synthesized using an Ugi/deprotection/cyclization (UDC) strategy, followed by a nucleophilic aromatic substitution reaction. This facile microwave-assisted method provided good yields and could potentially be used for the construction of a diverse library of quinolino[3,4-b]quinoxalin-6(5H)-ones for high-throughput screening in medicinal chemistry.
Ugi-based approaches to quinoxaline libraries
Azuaje, Jhonny,El Maatougui, Abdelaziz,Garcia-Mera, Xerardo,Sotelo, Eddy
supporting information, p. 403 - 411 (2014/09/17)
An expedient and concise Ugi-based unified approach for the rapid assembly of quinoxaline frameworks has been developed. This convergent and versatile method uses readily available commercial reagents, does not require advanced intermediates, and exhibits
A robust protocol for the synthesis of quinoxalines and 5 H -benzo[ e ][1,4]diazepines via the acidless Ugi reaction
Ayaz, Muhammad,Martinez-Ariza, Guillermo,Hulme, Christopher
, p. 1680 - 1684 (2014/08/05)
Concise two-step, one-pot protocols for the syntheses of quinoxalines and 5H-benzo[e][1,4]diazepines are reported. An 'acidless' Ugi reaction followed by a Boc-deprotection-cyclization sequence is shown to produce arrays of both functionalized scaffolds in good yield. Mono-N-Boc-protected diamines are employed to access quinoxalines and an analogous benzylic amine affords access to 5H-benzo[e][1,4]diazepines in conjunction with supporting reagents in the 'acidless' Ugi reaction. Both methodologies are robust, straightforward, and allow installation of at least three points of diversity in the resulting scaffolds. Georg Thieme Verlag Stuttgart New York.
