1609955-98-7Relevant academic research and scientific papers
Design, synthesis and evaluation of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease
Canto, Romulo F. S.,Barbosa, Flavio A. R.,Nascimento, Vanessa,De Oliveira, Aldo S.,Brighente, Ines M. C.,Braga, Antonio Luiz
, p. 3470 - 3477 (2014/05/20)
In this paper we report the design, synthesis and evaluation of a series of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease. The compounds show excellent results as acetylcholinesterase inhibitors, being as active as the standard drug. All these compounds also show very good antioxidant activity through different mechanisms of action. the Partner Organisations 2014.
