16100-41-7Relevant academic research and scientific papers
EGFR inhibitor and preparation method and application thereof
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, (2022/03/27)
The invention discloses an EGFR inhibitor compound as shown in a formula 1, pharmaceutically acceptable salts thereof and a preparation method of the EGFR inhibitor compound. The invention further discloses application of the compound and the pharmaceutically acceptable salt thereof in preparation of medicines for treating lung cancer, colorectal cancer, nasopharynx cancer, head and neck squamous cell carcinoma, gastric cancer, esophageal cancer, breast cancer, pancreatic cancer, liver cancer, cervical cancer, ovarian cancer, skin cancer and brain glioma. The invention also discloses a pharmaceutical composition containing the compound represented by the formula 1 or the pharmaceutically acceptable salt thereof.
Heterocyclen-Synthesen mit Monothiomalonsaeure-Amiden: Synthese von 3-Oxo-2,3-dihydroisothiazolopyridinen und 3-Oxo-2,3-dihydroisothiazolopyrimidinen
Schaper, Wolfgang
, p. 861 - 867 (2007/10/02)
The monothiomalonic acid amides 5, prepared from cyanoacetamides 4 and hydrogen sulphide, react with diketones 6 or aldehyde derivatives 7 to give the 2-thioxo-1,2-dihydropyridine-3-carboxamides 8 which can be cyclised to the 3-oxo-2,3-dihydroisothiazolo
