161003-70-9

Upstream product

• 161003-68-5 (7E)-(1S,3S,5R,6R)-1-acetoxy-6-(1,3-benzodithiol-2-yloxy)-3,5-cyclo-9,10-seco-23,24-dinor-7,10⁽¹⁹⁾-choladien-22-yl tosylate 
• 161003-64-1 (1S,6R)-1-acetoxy-6-(1,3-benzodithiol-2-yloxy)-3,5-cyclovitamin D₂ 
• 161003-73-2 (7E)-(1S,3S,5R,6R)-1-acetoxy-6-(1,3-benzodithiol-2-yloxy)-3,5-cyclo-9,10-seco-23,24-dinor-7,10⁽¹⁹⁾-choladien-22-al 
• 161003-67-4 (7E)-(1S,3S,5R,6R)-1-acetoxy-6-(1,3-benzodithiol-2-yloxy)-3,5-cyclo-9,10-seco-23,24-dinor-7,10⁽¹⁹⁾-cholien-22-ol 
• 161003-63-0 (1S,6R)-1-hydroxy-6-(1,3-benzodithiol-2-yloxy)-3,5-cyclovitamin D₂ 
• 161003-62-9 (6R)-6-(1,3-benzodithiol-2-yloxy)-3,5-cyclovitamin D₂ 
• 83872-57-5 2-Methyl-4-phenylsulfonyl-2-<(tetrahydropyran-2-yl)oxy>butan 
• 161003-69-6 (7E)-(1S,3S,5R,6R)-1-acetoxy-6-(1,3-benzodithiol-2-yloxy)-22-iodo-3,5-cyclo-9,10-seco-23,24-dinor-7,10⁽¹⁹⁾-choladiene 

Downstream Products

• 32222-06-3 calcitriol 

Relevant academic research and scientific papers

Convenient synthesis of 1α,25-dihydroxyvitamin D3 from vitamin D2

(1S,6R)-1-Acetoxy-6-(1,3-benzodithiol-2-yloxy)-3,5-cyclovitamin D2 (7) was synthesized from vitamin D2 by five steps. The new compound 7 was ozonized regioselectively and subsequently reduced, leading to (7E)-(1S,3S,5R,6R)-1-acetoxy-6-(1,3-benzodithiol-2-yloxy)-3,5-cyclo-9, 10-seco-23,24-dinor-7,10(19)-choladien-22-ol (11). The alcohol 11 obtained as a key intermediate was tosylated, iodinated, and coupled with 2-methyl-4-phenylsulfonyl-2-(tetrahydropyranyloxy)butane to give (1S,6R)-1-hydroxy-6-(1,3-benzodithiol-2-yloxy)-23-phenylsulfonyl-25-te trahydropyranyloxy-3,5-cyclovitamin D3 (16). By desulfonylation and hydrolysis of the compound 16 1α,25-dihydroxyvitamin D3 was obtained selectively.