1610051-84-7

Basic information

• Product Name: C₂₂H₁₅ClN₄O₃S
• CAS NO: 1610051-84-7
• Molecular Weight: 450.905
• Mol File: 1610051-84-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₂H₁₅ClN₄O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₁₅ClN₄O₃S(1610051-84-7)
• EPA Substance Registry System: C₂₂H₁₅ClN₄O₃S(1610051-84-7)

Safety Data

• Hazardous Substances Data: 1610051-84-7(Hazardous Substances Data)

Upstream product

• 20776-50-5 2-amino-4-bromobenzoic acid 
• 1610051-94-9 C₁₆H₉BrClN₃O 
• 850568-74-0 3-(dihydroxyboranyl)benzene-1-sulfonamide 

Downstream Products

• 1610051-39-2 C₂₃H₁₇ClN₄O₃S 

Relevant articles and documents

Synthesis and SAR of substituted pyrazolo[1,5-a]quinazolines as dual mGlu2/mGlu3 NAMs

Herein we report the design and synthesis of a series of substituted pyrazolo[1,5-a]quinazolin-5(4H)-ones as negative allosteric modulators of metabotropic glutamate receptors 2 and 3 (mGlu2 and mGlu3, respectively). Development of this series was initiated by reports that pyrazolo[1,5-a]quinazoline-derived scaffolds can yield compounds with activity at group II mGlu receptors which are prone to molecular switching following small structural changes. Several potent analogues, including 4-methyl-2-phenyl-8-(pyrimidin-5-yl)pyrazolo[1,5-a]quinazolin-5(4H)-one (10b), were discovered with potent in vitro activity as dual mGlu2/mGlu 3 NAMs, with excellent selectivity versus the other mGluRs.