1610052-53-3Relevant academic research and scientific papers
Organocatalytic one-pot synthesis of highly substituted pyridazines from morita-baylis-hillman carbonates and diazo compounds
Mao, Haibin,Lin, Aijun,Tang, Zhongkai,Hu, Hongwen,Zhu, Chengjian,Cheng, Yixiang
, p. 2454 - 2458 (2014)
A biologically inspired organocatalytic one-pot synthesis of highly functionalized pyridazines, which are ubiquitous structural units in a number of biologically active compounds, has been developed by starting from readily available diazo compounds and Morita-Baylis-Hillman (MBH) carbonates. Under mild reaction conditions, this synthetic route tolerated significant substrate variation to deliver a broad range of substituted products, including CF 3-substituted pyridazines derivatives. Moreover, the introduction of trifluoromethyl groups into the ring of pyridazine could be completed conveniently from 2,2,2-trifluorodiazoethane. Go bio! A biologically inspired organocatalytic one-pot synthesis of highly functionalized pyridazines has been developed by starting from readily available diazo compounds and Morita-Baylis-Hillman (MBH) carbonates (see scheme; DABCO=1,4-diazobicyclo[2.2. 2]octane, Boc=tert-butoxycarbonyl). Under mild reaction conditions, this synthetic route tolerated significant substrate variation to deliver a broad range of substituted products, including CF3-substituted pyridazines derivatives. Copyright
