16101-71-6Relevant academic research and scientific papers
Synthesis and biological evaluation of ABCD ring fragments of the kibdelones
Sloman, David L.,Mitasev, Branko,Scully, Stephen S.,Beutler, John A.,Porco Jr., John A.
supporting information; experimental part, p. 2511 - 2515 (2011/05/04)
Arylation goes platinum: The synthesis of the ABCD ring fragments of the kibdelones has been achieved through a novel PtIV-catalyzed arylation of a quinone monoketal followed by photocyclization (see scheme). Biological evaluation in the NCI 60-cell screen revealed that the kibdelone ABCD ring analogues were about 2000 times less active than kibdelones B and C, suggesting that the tetrahydroxanthone structure of the kibdelones is crucial for cytotoxicity. Copyright
