161024-54-0

Basic information

• Product Name: C₂₄H₂₆F₃N₃O₃*C₈H₈O₃
• CAS NO: 161024-54-0
• Molecular Weight: 613.634
• Mol File: 161024-54-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₆F₃N₃O₃*C₈H₈O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₆F₃N₃O₃*C₈H₈O₃(161024-54-0)
• EPA Substance Registry System: C₂₄H₂₆F₃N₃O₃*C₈H₈O₃(161024-54-0)

Safety Data

• Hazardous Substances Data: 161024-54-0(Hazardous Substances Data)

Upstream product

• 160969-03-9 1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene 
• 175837-01-1 1-acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrile 
• 175837-07-7 1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile 
• 17199-29-0 (S)-Mandelic acid 

Relevant articles and documents

Enantioselective synthesis of (-)-(R) Silodosin by ultrasound-assisted diastereomeric crystallization

Enantioselective synthesis of clinically approved drug - Silodosin for the treatment of benign prostatic hyperplasia from the commercially available compounds 1-acetyl-5-(2-aminopropyl) indoline-7-carbonitrile A and 2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl methanesulfonate C is explored. Key step in the synthesis is chiral resolution of intermediate 1, which was achieved by a simple diastereomeric crystallization using (S)-(+)-mandelic acid assisted by ultrasonication. The present synthetic strategy has lesser number of steps and is vastly improved the overall yield in this short route towards target compound - Silodosin.