1610368-30-3Relevant academic research and scientific papers
Synthesis method of 2H-indazole and derivatives thereof
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Paragraph 0027-0040, (2020/12/15)
The invention discloses a synthetic reaction of 2H-indazole and derivatives thereof under a metal-free condition. The new strategy has the advantages of no metal participation, wide substrate range and good functional group compatibility, and an efficient
Efficient synthesis of 2-aryl-2: H -indazoles by base-catalyzed benzyl C-H deprotonation and cyclization
Gao, Wen-Xia,Jin, Guo-Qing,Liu, Miao-Chang,Wu, Hua-Yue,Zhou, Yun-Bing
, p. 14617 - 14620 (2020/12/02)
A straightforward and efficient method for the preparation of 2-aryl-2H-indazoles from ortho-alkyl substituted azoxybenzenes is presented. The reaction proceeds through base-catalyzed benzyl C-H deprotonation and cyclization to afford 2-aryl-2H-indazoles
Assembly of Fully Substituted 2H-Indazoles Catalyzed by Cu2O Rhombic Dodecahedra and Evaluation of Anticancer Activity
Panchangam, Rajeeva Lochana,Manickam, Venkatraman,Chanda, Kaushik
, p. 262 - 272 (2019/01/04)
Simultaneous C?N, and N?N bond-forming methods for one-pot transformations are highly challenging in synthetic organic chemistry. In this study, the Cu2O rhombic dodecahedra-catalyzed synthesis of 2H-indazoles is demonstrated with good to excellent yields from readily available chemicals. This one-pot procedure involves Cu2O nanoparticle-catalyzed consecutive C?N, and N?N bond formation followed by cyclization to yield 2H-indazoles with broad substrate scope and high functional group tolerance. Various cell-based bioassay studies demonstrated that 2H-indazoles inhibit the growth of cancer cells, typically through induction of apoptosis in a dose-dependent manner. Moreover, 2H-indazoles tested in the MDA-MB-468 cell line were capable of inhibiting cancer cell migration and invasion. Thus, it is shown that 2H-indazoles have potent in vitro anticancer activity that warrant further investigation of this compound class.
Regioselective synthesis of 2 H-indazoles using a mild, one-pot condensation-cadogan reductive cyclization
Genung, Nathan E.,Wei, Liuqing,Aspnes, Gary E.
supporting information, p. 3114 - 3117 (2014/06/23)
An operationally simple and efficient one-pot synthesis of 2H-indazoles from commercially available reagents is reported. Ortho-imino-nitrobenzene substrates, generated via condensation, undergo reductive cyclization promoted by tri-n-butylphosophine to afford substituted 2H-indazoles under mild reaction conditions. A variety of electronically diverse ortho-nitrobenzaldehydes and anilines were examined. To further extend the scope of the transformation, aliphatic amines were also employed to form N2-alkyl indazoles selectively under the optimized reaction conditions.
