1610411-24-9

Basic information

• Product Name: 4-(5-(4-chlorophenyl)-1-methyl-3-(thiophen-2-yl)-1,6-dihydropyrrolo[2,3-c]pyrazol-4-yl)-1-methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine
• Synonyms: 4-(5-(4-chlorophenyl)-1-methyl-3-(thiophen-2-yl)-1,6-dihydropyrrolo[2,3-c]pyrazol-4-yl)-1-methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine
• CAS NO: 1610411-24-9
• Molecular Weight: 491.04
• Mol File: 1610411-24-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(5-(4-chlorophenyl)-1-methyl-3-(thiophen-2-yl)-1,6-dihydropyrrolo[2,3-c]pyrazol-4-yl)-1-methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-(4-chlorophenyl)-1-methyl-3-(thiophen-2-yl)-1,6-dihydropyrrolo[2,3-c]pyrazol-4-yl)-1-methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine(1610411-24-9)
• EPA Substance Registry System: 4-(5-(4-chlorophenyl)-1-methyl-3-(thiophen-2-yl)-1,6-dihydropyrrolo[2,3-c]pyrazol-4-yl)-1-methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine(1610411-24-9)

Safety Data

• Hazardous Substances Data: 1610411-24-9(Hazardous Substances Data)

Upstream product

• 4996-21-8 1-(4-chloro-phenyl)-2,2-dihydroxy-ethanone 
• 118430-78-7 1-methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine 

Relevant articles and documents

Domino reaction of arylglyoxals with pyrazol-5-amines: Selective access to pyrazolo-fused 1,7-naphthyridines, 1,3-diazocanes, and pyrroles

New multicomponent domino reactions of arylglyoxals with pyrazol-5-amines have been established, providing selective access to unprecedented pyrazolo-fused 1,7-naphthyridines, 1,3-diazocanes, and pyrroles (up to 52 examples). The unreported dipyrazolo-fused 1,7-naphthyridines were regioselectively synthesized through a special double [3 + 2 + 1] heteroannulation accompanied by direct C-C formation between two electrophilic sites of arylglyoxals. The unusual [3 + 3 + 1 + 1] cyclization resulted in 20 examples of novel dipyrazolo-fused 1,3-diazocanes, whereas pyrrolo[2,3-c] pyrazoles were obtained in good yields by varying arylglyoxals 1 and pyrazol-5-amines 2 in the ratio 1:2. Mechanisms of formation of these three new types of heterocycles are also proposed.