1610421-06-1

Basic information

• Product Name: (2-(1,3-dioxan-2-yl)phenyl)tributylstannane
• Synonyms: (2-(1,3-dioxan-2-yl)phenyl)tributylstannane
• CAS NO: 1610421-06-1
• Molecular Weight: 453.253
• Mol File: 1610421-06-1.mol

Chemical Properties

• CAS DataBase Reference: (2-(1,3-dioxan-2-yl)phenyl)tributylstannane(CAS DataBase Reference)
• NIST Chemistry Reference: (2-(1,3-dioxan-2-yl)phenyl)tributylstannane(1610421-06-1)
• EPA Substance Registry System: (2-(1,3-dioxan-2-yl)phenyl)tributylstannane(1610421-06-1)

Safety Data

• Hazardous Substances Data: 1610421-06-1(Hazardous Substances Data)

Upstream product

• 1461-22-9 tributyltin chloride 
• 61568-53-4 2-(ortho-bromophenyl)-1,3-dioxane 

Downstream Products

• 1610421-16-3 6-benzylbenzo[b]phenanthridine-5,7,12(6H)-trione 
• 1610421-17-4 6-(2-(trifluoromethyl)benzyl)benzo[b]phenanthridine-5,7,12(6H)-trione 
• 1610421-18-5 6-(4-chlorobenzyl)benzo[b]phenanthridine-5,7,12(6H)-trione 
• 1610421-07-2 2-(2-(1,3-dioxan-2-yl)phenyl)naphthalene-1,4-dione 

Relevant articles and documents

Bioreductively activated reactive oxygen species (ROS) generators as MRSA inhibitors

The number of cases of drug resistant Staphylococcus aureus infections is on the rise globally and new strategies to identify drug candidates with novel mechanisms of action are in urgent need. Here, we report the synthesis and evaluation of a series of benzo[b]phenanthridine-5,7,12(6H)-triones, which were designed based on redox-active natural products. We find that the in vitro inhibitory activity of 6-(prop-2-ynyl)benzo[b]phenanthridine-5,7,12(6H)-trione (1f) against methicillin-resistant Staphylococcus aureus (MRSA), including a panel of patient-derived strains, is comparable or better than vancomycin. We show that the lead compound generates reactive oxygen species (ROS) in the cell, contributing to its antibacterial activity.