1610455-70-3

Basic information

• Product Name: N-(4-cyano-2,3,5,6-tetrafluorophenyl)-1-((1,3-dioxoisoindolin-2-yl)methyl)cyclobutanecarboxamide
• CAS NO: 1610455-70-3
• Molecular Weight: 431.346
• Mol File: 1610455-70-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-cyano-2,3,5,6-tetrafluorophenyl)-1-((1,3-dioxoisoindolin-2-yl)methyl)cyclobutanecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-cyano-2,3,5,6-tetrafluorophenyl)-1-((1,3-dioxoisoindolin-2-yl)methyl)cyclobutanecarboxamide(1610455-70-3)
• EPA Substance Registry System: N-(4-cyano-2,3,5,6-tetrafluorophenyl)-1-((1,3-dioxoisoindolin-2-yl)methyl)cyclobutanecarboxamide(1610455-70-3)

Safety Data

• Hazardous Substances Data: 1610455-70-3(Hazardous Substances Data)

Upstream product

• 1552565-80-6 C₁₄H₁₃NO₄ 
• 1610455-63-4 C₁₆H₁₇NO₄ 
• 1195-81-9 ethyl 1-(hydroxymethyl)cyclobutanecarboxylate 
• 3779-29-1 diethyl cyclobutane-1,1-dicarboxylate 
• 17823-38-0 4-amino-2,3,5,6-tetrafluorobenzonitrile 
• 1610455-67-8 C₁₄H₁₂ClNO₃ 

Relevant articles and documents

Palladium(II)-catalyzed enantioselective C(sp3)-H activation using a chiral hydroxamic acid ligand

An enantioselective method for Pd(II)-catalyzed cross-coupling of methylene β-C(sp3)-H bonds in cyclobutanecarboxylic acid derivatives with arylboron reagents is described. High yields and enantioselectivities were achieved through the development of chiral mono-N-protected α-amino-O- methylhydroxamic acid (MPAHA) ligands, which form a chiral complex with the Pd(II) center. This reaction provides an alternative approach to the enantioselective synthesis of cyclobutanecarboxylates containing α-chiral quaternary stereocenters. This new class of chiral catalysts also show promises for enantioselective β-C(sp3)-H activation of acyclic amides.