1610459-40-9

Upstream product

• 501381-03-9 (+/-)-methylphenylphosphane borane 
• 111409-79-1 1-bromo-2-(triisopropylsilyl)acetylene 

Downstream Products

• 1610459-45-4 1-benzyl-4-(borane(methyl)phenylphosphino)-1H-1,2,3-triazole 
• 1610459-46-5 1-(4-bromophenyl)-4-(borane(methyl)phenylphosphino)-1H-1,2,3-triazole 
• 1610459-56-7 1-benzyl-4-(phenyl(methyl)phosphino)-1H-1,2,3-triazole 

Relevant academic research and scientific papers

Silyl alkynylphosphine-boranes: Key precursors of triazolylphosphines via tandem desilylation-Click chemistry

A versatile synthesis of 1,2,3-triazolyl-4-phosphines from the borane complexes of phosphino-alkynes is reported. The efficiency of the procedure relies on the use of readily available silyl-protected alkynylphosphine-boranes, which were subjected to desilylation with TBAF followed by copper-catalyzed azide-alkyne-cycloaddition in one pot. Subsequent treatment with DABCO afforded the targeted triazolylphosphines in high yields. The reported method was applied to the synthesis of the first example of an enantioenriched P-stereogenic triazolylphosphine (98.8% ee). This journal is the Partner Organisations 2014.