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Upstream product

• 92553-10-1 3-hydroxy-3-(4-methoxyphenyl)-2,3-dihydro-1H-isoindol-1-one 
• 501-65-5 diphenyl acetylene 

Relevant academic research and scientific papers

Iridium-catalyzed asymmetric [3+2] annulation of aromatic ketimines with alkynes via C-H activation: Unexpected inversion of the enantioselectivity induced by protic acids

A cationic iridium/binap catalyst enabled the asymmetric [3+2] annulation of cyclic N-acyl ketimines with internal alkynes via C-H activation to give spiroaminoindene derivatives with high enantioselectivity. The stereochemical course of this annulation was switchable by acid additives.

Catalytic [3 + 2] annulation of ketimines with alkynes via C-H activation by a cationic iridium(cod) complex

[3 + 2] Annulation of ketimines with internal and terminal alkynes proceeded via C-H activation to give aminoindene derivatives in high yields, which is catalyzed by a cationic iridium complex coordinated with 1,5-cyclooctadiene (cod). This journal is the Partner Organisations 2014.