16105-49-0

Basic information

• Product Name: 5-ethoxy-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
• CAS NO: 16105-49-0
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 204.2252
• Mol File: 16105-49-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 289.3°C at 760 mmHg
• Flash Point: 128.8°C
• Density: 1.19g/cm³
• Vapor Pressure: 0.00222mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 5-ethoxy-2-phenyl-2,4-dihydro-3H-pyrazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ethoxy-2-phenyl-2,4-dihydro-3H-pyrazol-3-one(16105-49-0)
• EPA Substance Registry System: 5-ethoxy-2-phenyl-2,4-dihydro-3H-pyrazol-3-one(16105-49-0)

Safety Data

• Hazardous Substances Data: 16105-49-0(Hazardous Substances Data)

Upstream product

• 574-61-8 benzophenone N-phenylhydrazone 
• 108-86-1 bromobenzene 
• 337533-95-6 (N'-benzhydrylidene-N-phenyl-hydrazinocarbonyl)-acetic acid ethyl ester 
• 64-17-5 ethanol 
• 19933-22-3 2,4-dihydro-5-hydroxy-2-phenyl-3H-pyrazol-3-one 
• 99365-96-5 4-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-5-ethoxy-2-phenyl-2,4-dihydro-pyrazol-3-one 

Downstream Products

• 84200-12-4 7-Ethoxy-2,2-dimethyl-5-phenyl-1-oxa-5,6-diaza-spiro[2.4]hept-6-en-4-one 
• 99367-98-3 4-Acetoxy-3-ethoxy-5-hydroxy-1-phenyl-pyrazol 
• 99367-90-5 5-Ethoxy-2-phenyl-2H-pyrazole-3,4-diol 
• 84263-05-8 5-Ethoxy-4-isopropylidene-2-phenyl-2,4-dihydro-pyrazol-3-one 
• 99365-96-5 4-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-5-ethoxy-2-phenyl-2,4-dihydro-pyrazol-3-one 

Relevant articles and documents

Novel application of the palladium-catalyzed N-arylation of hydrazones to a versatile new synthesis of pyrazoles

A versatile synthesis of pyrazoles from aryl benzophenone hydrazones was demonstrated with a variety of 1,3-bifunctional substrates under acidic conditions. The obtained regioselectivity is consistent with transhydrazonation followed by subsequent cycliza

Investigations on the Hydrolytic Stability of 4-Arylmethylidene-2-pyrazolin-5-ones

The 4-Arylmethylidene-2-pyrazoline-5-ones S are not stable under aqueous alkaline conditions.By the substitution of R3 with electron donor substituents S reacts preferably yielding aldehyde A and 2-pyrazoline-5-one P, while with electron acceptor substituents S forms 4,4'-arylmethylidene-bis-2-pyrazoline-5-one B.The intermediate of hydrolysis is 4-(arylhydroxymethyl)-2-pyrazoline-5-one SOH.The second order rate constants of the reactions of S with hydroxidions and with 2-pyrazoline-5-ones P(-) are determined.The dependence of the hydrolytic decomposition of S on the pH value, substituents and temperature is suitable for the intermediate formation of SOH.