1610524-30-5

Basic information

• Product Name: C₃₁H₄₀N₂O₃
• CAS NO: 1610524-30-5
• Molecular Weight: 488.67
• Mol File: 1610524-30-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₁H₄₀N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₁H₄₀N₂O₃(1610524-30-5)
• EPA Substance Registry System: C₃₁H₄₀N₂O₃(1610524-30-5)

Safety Data

• Hazardous Substances Data: 1610524-30-5(Hazardous Substances Data)

Upstream product

• 2316-64-5 5-bromo-2-hydroxybenzyl alcohol 
• 52113-69-6 6-bromo-2,2-dimethyl-4H-benzo[1,3]dioxine 
• 54030-34-1 1-(2,2-dimethyl-4H-benzo[d][1,3]dioxan-6-yl)ethanone 
• 102293-80-1 2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone 
• 530118-35-5 C₃₅H₃₆BrNO₅ 
• 530118-37-7 C₃₅H₃₈BrNO₅ 
• 1610524-04-3 C₄₉H₅₈N₂O₅ 

Relevant articles and documents

Multivalent design of long-acting β2-adrenoceptor agonists incorporating biarylamines

A series of potent β2-adrenoceptor agonists incorporating a biarylamine secondary binding group was identified. The previously reported milveterol (5), identified by a multivalent approach and containing a typical β2-agonist primary binding group linked via a phenethylamine linker to a hydrophilic secondary binding group, served as an initiation point. A more hydrophobic set of secondary binding groups was explored, prepared rapidly from a common intermediate by Buchwald-Hartwig amination. TD-5471 (25), a potent and selective full agonist of the human β2- adrenoceptor, was identified as the most promising agent. It is potent, with slow onset in an in vitro guinea pig trachea model and shows a dose-dependent and long duration of action in an in vivo guinea pig model of bronchoprotection. TD-5471 is structurally differentiated from milveterol and its long duration of action is consistent with a correlation with hydrophobicity observed in other long-acting β2-agonist discovery programs.