1610620-26-2

Basic information

• Product Name: 1-(tert-butylamino)-1-oxo-4-phenylbutan-2-yl (4-chlorophenyl)phosphinate
• Synonyms: 1-(tert-butylamino)-1-oxo-4-phenylbutan-2-yl (4-chlorophenyl)phosphinate
• CAS NO: 1610620-26-2
• Molecular Weight: 393.85
• Mol File: 1610620-26-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(tert-butylamino)-1-oxo-4-phenylbutan-2-yl (4-chlorophenyl)phosphinate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(tert-butylamino)-1-oxo-4-phenylbutan-2-yl (4-chlorophenyl)phosphinate(1610620-26-2)
• EPA Substance Registry System: 1-(tert-butylamino)-1-oxo-4-phenylbutan-2-yl (4-chlorophenyl)phosphinate(1610620-26-2)

Safety Data

• Hazardous Substances Data: 1610620-26-2(Hazardous Substances Data)

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 119072-55-8 tert-butylisonitrile 
• 22336-21-6 (4-chlorophenyl)phosphinic acid 

Downstream Products

• 1610620-51-3 1-(tert-butylamino)-1-oxo-4-phenylbutan-2-yl (4-chlorophenyl)(hydroxy(phenyl)methyl)phosphinate 

Relevant articles and documents

A one-pot o-phosphinative passerini/pudovik reaction: Efficient synthesis of highly functionalized α-(phosphinyloxy)amide derivatives

A one-pot O-phosphinative Passerini/Pudovik reaction has been developed, based on reacting aldehydes, isocyanides, and phosphinic acids followed by the addition of second aldehydes to form the corresponding α-(phosphinyloxy) amide derivatives. This is the first reported instance of a Passerini-type, isocyanide-based multicomponent reaction using a phosphinic acid instead of a carboxylic acid. The nucleophilicity of the phosphinate group allows a subsequent catalytic Pudovik-type reaction, affording the highly functionalized α-(phosphinyloxy)amide derivative in high yield. A wide range of aldehydes and isocyanides are applicable to this reaction.