1610673-08-9Relevant academic research and scientific papers
Enantioselective syntheses of bicyclic lactams based on iridium-catalyzed asymmetric allylic substitution and heck cyclization
Satyanarayana, Gedu,Helmchen, Guenter
, p. 2242 - 2252 (2014/04/17)
A sequence of reactions that include an iridium-catalyzed regio- and enantioselective allylic amination, the formation of an amide, a ruthenium-catalyzed ring-closing metathesis, and an intramolecular Heck reaction allows for the preparation of [3,3,1]- and [4,3,1]-bicyclic amides. The target compounds have a nitrogen atom at the bridgehead, a nonplanar amide moiety, and a stereogenic center at the one-carbon bridge.
