1610680-24-4Relevant articles and documents
Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK
Laufer, Radoslaw,Li, Sze-Wan,Liu, Yong,Ng, Grace,Lang, Yunhui,Feher, Miklos,Brokx, Richard,Beletskaya, Irina,Hodgson, Richard,Mao, Guodong,Plotnikova, Olga,Awrey, Donald E.,Mason, Jacqueline M.,Wei, Xin,Lin, Dan Chi-Chia,Che, Yi,Kiarash, Reza,Madeira, Brian,Fletcher, Graham C.,Mak, Tak W.,Bray, Mark R.,Pauls, Henry W.
supporting information, p. 3562 - 3566 (2016/07/21)
TTK/Mps1 is a key kinase controlling progression of cell division via participation in the mitotic spindle assembly checkpoint and is overexpressed in a number of human cancers. Herein we report the discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-y